The Grade 12 Chemistry course is meticulously structured to provide students with a profound understanding of chemical principles and their applications in various real-world contexts. Building upon foundational knowledge from previous grades, the course delves into complex topics that are pivotal for students aspiring to pursue careers in science, technology, engineering, and medicine.​

In the first unit, students explore acid–base equilibria, examining different acid–base theories, the behavior of weak acids and bases, buffer solutions, and titration techniques. This foundational knowledge is crucial for understanding chemical reactions in both laboratory and biological systems.​

The second unit focuses on electrochemistry, where students study redox reactions, electrolysis, and the quantitative aspects of electrochemical processes. They also investigate the industrial applications of electrolysis, gaining insights into how chemical reactions are harnessed to produce essential materials.​

Industrial chemistry, covered in the third unit, provides students with an understanding of how raw materials are transformed into valuable products. This includes the manufacturing processes of fertilizers, insecticides, and herbicides, as well as an examination of Ethiopia's manufacturing industries.​

The fourth unit introduces students to polymers, exploring their synthesis, classification, and diverse applications. Students learn about the significance of polymers in various industries, including plastics, textiles, and biomedical devices.​

The final unit addresses environmental chemistry, where students examine the chemical aspects of environmental issues. Topics include the components of the environment, natural chemical cycles, pollution, climate change, and sustainable chemistry practices.​

Throughout the course, students engage in hands-on experiments, problem-solving activities, and critical discussions that enhance their scientific literacy and analytical skills. By integrating theoretical concepts with practical applications, the Grade 12 Chemistry course equips students with the knowledge and competencies necessary for academic success and informed citizenship in a scientifically complex world.​